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Nam Ki Lee

Principal Investigator

Department of Chemistry, SNU

Phone : +82 2-880-2234

Office : 503-dong 423-ho




2005.8                Ph. D. in Physical Chemistry, Seoul National University

                            Thesis: “Single-molecule Fluorescence Resonance Energy Transfer by                                                          Alternating-Laser Excitation”

                            Advisor: Prof. Seong Keun Kim, Co-advisor: Prof. Shimon Weiss (UCLA)

2000.2                M. Sc. in Physical Chemistry, Seoul National University

1998.2                 B.S. in Chemistry, Seoul National University


2021.9-present      Vice Chair, Department of Chemistry, Seoul National University

2019.9-2021.8         Associate Director, Science & Policy Advanced Research Course, College of                                          Natural Science

2017.3-present       Associate Professor and Professor, Department of Chemistry, Seoul National                                        University

2013.9-2017.2         Associate Professor, Department of Physics & School of Interdisciplinary                                              Bioscience and Bioengineering, POSTECH

2009.1-2013.8         Assistant Professor, School of Interdisciplinary Bioscience and Bioengineering                                      & Department of Physics, POSTECH

2006.5–2008.12     Postdoctoral Fellow, Harvard University (Advisor: Prof. X. Sunney Xie)

2005.9–2006.4      Postdoctoral Fellow, Seoul National University (Advisor: Prof. S. K. Kim)

2002.2 –2003.8     Visiting scholar, University of California at Los Angeles (Advisor: Prof. Shimon Weiss)


2021        Award for Excellent Research, College of Natural Science, Seoul National University

2019        Sigma-Aldrich Chemist Award of Korean Chemical Society

2018        Distinguished Lectureship Award of the Chemical Society of Japan

2017        Excellent Teaching Award of Pohang University of Science and Technology

2016        Award for Excellent Research Project by Ministry of Education, South Korea

2014        Advisor of the recipient of Samsung HumanTech paper award (Gold Medal in Basic Science                 & Technology)

2005       The Korean Chemical Society Award for Outstanding Ph.D. Thesis

2003       Award for Excellent Papers (conferred by the “Brain Korea 21” program by Ministry of                            Education & Human Resources Development)

2002       Award for Excellent Papers (conferred by the “Brain Korea 21” program by Ministry of                             Education & Human Resources Development)

1996        Korea Research Foundation Scholarship


        J. Yi#, S. Yeou#, N. K. Lee*, "DNA bending force facilitates Z-DNA formation under physiological salt conditions", J. Am. Chem. Soc. 144, 29, 13137-13145 (2022).

•        Y. Cho#, H. J. An#, T. Kim, C. Lee*, N. K. Lee*, “Mechanism of Cyanine5 to Cyanine3 photoconversion and its application for high-density single-particle tracking in a living cell”, J. Am. Chem. Soc. 143, 14125-14135 (2021).

•        J. Hwang, J.-Y. Kim, C. Kim, S. Park, S. Joo, S. K. Kim*, N. K. Lee*, "Single-molecule observation of ATP-independent SSB displacement by RecO in Deinococcus radiodurans", eLife, 9, e50945 (2020).

•        S. Yang#, S. H. Kim#, D.-K. Kim, H. J. An, J. B. Son, A. H. Gynnå, N. K. Lee*, " Transcription and translation contribute to gene locus relocation to the nucleoid periphery in E.coli", Nat. Commun. 10, 5131 (2019).

•        C. Kim, O. Lee, J.-Y. Kim, W. Sung, N. K. Lee,* “Dynamic release of bending stress in short dsDNA by a kink and forks”, Angew. Chem. Int. Ed. 54, 8943–8947 (2015).

•      J.-Y. Kim, C. Kim, N. K. Lee,* “Real-time sub-millisecond single-molecule FRET dynamics of freely diffusing molecules with liposome tethering”, Nat. Commun. 6, 6992 (2015).

•        D.-H. Kim#, K. Zhou#, D.-K. Kim#, S. Park, J. Noh, Y. Kwon, D. Kim, N. W. Song, J.-B. Lee, P.-G. Suh, N. K. Lee*, S. H. Ryu,* “Analysis of Interactions between the Epidermal Growth Factor Receptor and Soluble Ligands on the Basis of Single-Molecule Diffusivity in the Membrane of Living Cells”, Angew. Chem. Int. Ed. 54, 7028–7032 (2015).

•        S. Yang, S. Kim, Y. R. Lim, C. Kim, H. J. An, J-H. Kim, J. Sung*, N. K. Lee,* “Contribution of RNA polymerase concentration variation to protein expression noise”, Nat. Commun. 5, 4761 (2014).

•        B. K. Choi,# M.-G. Choi, # J.-Y. Kim,# Y. Yang, Y. Lai, D.-H. Kweon, N. K. Lee,* Y.-K. Shin,* “Large α-Synuclein oligomers inhibit neuronal SNARE-mediated vesicle docking”, Proc. Natl. Acad. Sci. USA 110, 4087–4092 (2013).

•   J.Y. Kim,# B. K Choi, # M. G Choi, S. A. Kim, Y. K. Shin,* N. K Lee,* “Solution single-vesicle assay reveals PIP2 is required for the sequential actions of synaptotagmin-1 on SNAREs”, EMBO J. 31, 2144-2155  (2012).


Methods : Single-molecule Fluorescence and FRET, Single Fluorescent Protein imaging in living cell, Super-resolution optical imaging (PALM), Single cell analysis on microfluidic device

Biology : Signal transduction by EGFR and GPCR, Membrane protein dynamics, Transcriptional dynamics, DNA recombination, Neurotransmitter release, Parkinson’s and Alzheimer’s disease


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